Operating across the whole of the UK with a combined budget of more than £7 billion, UK Research and Innovation (UKRI) brings together the seven UK research councils, Innovate UK, and Research England. UKRI works in partnership with universities, research organisations, businesses, charities, and the UK government to create the best possible environment for research and innovation to flourish. The 'Medical Research Council‘ MRC supports medical research, spending around £800 million each year by providing research grants and career awards to scientists. Funding opportunities are either researcher-led or MRC strategic. Researcher-led proposals are reviewed at board and panel meetings, with funding available for any area of science relevant to the MRC, and provide support on a range of scales across career stages, from fundamental to translational research.